Fields »
ABOUT
HELP
BLOG
GEMIN5

GENERAL INFORMATION

Gene name

 GEMIN5

Gene description

 Gem (nuclear organelle) associated protein 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA037393
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), liver cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Liver cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037393

GENE INFORMATION

Gene name

 GEMIN5

Synonyms

Description

 Gem (nuclear organelle) associated protein 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 5

Cytoband

 q33.2

Chromosome location (bp)

 154887416 - 154938209

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082516 (version 83.38)

Entrez gene

 25929

UniProt

 Q8TEQ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEQ6

Antibodypedia

 GEMIN5 antibodies

PROTEIN BROWSER
GEMIN5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEMIN5-001
ENSP00000285873
ENST00000285873
Q8TEQ6 [Direct mapping]
Gem-associated protein 5
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016604 [nuclear body]
GO:0017069 [snRNA binding]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0097504 [Gemini of coiled bodies]
Show all
 1508 aa
168.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.