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GEMIN5

GENERAL INFORMATION

Gene name

 GEMIN5

Gene description

 Gem (nuclear organelle) associated protein 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA037393
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GEMIN5

Synonyms

Description

 Gem (nuclear organelle) associated protein 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 5

Cytoband

 q33.2

Chromosome location (bp)

 154887416 - 154938209

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000082516 (version 83.38)

Entrez gene

 25929

UniProt

 Q8TEQ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEQ6

Antibodypedia

 GEMIN5 antibodies

PROTEIN BROWSER
GEMIN5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEMIN5-001
ENSP00000285873
ENST00000285873
Q8TEQ6 [Direct mapping]
Gem-associated protein 5
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016604 [nuclear body]
GO:0017069 [snRNA binding]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0097504 [Gemini of coiled bodies]
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 1508 aa
168.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.