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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AKR1B1
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AKR1B1

Gene description

Aldo-keto reductase family 1, member B1 (aldose reductase)

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, BJ hTERT+)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA026425 , HPA052751 , CAB027391 , CAB047353
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PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (unfavourable) and urothelial cancer (unfavourable).
Stomach cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA026425
HPA052751
CAB027391
CAB047353

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak cytoplasmic positivity was displayed in a subset of tumor cells in a few cancers including several cases of glioma.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic or nuclear membranous positivity was observed in tumor cells in urothelial, basal cell and squamous cell carcinomas. All other cancer types were essentially negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and nuclear positivity was displayed in a subset of tumor cells in a few cancers including glioma, renal and thyroid cancer.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

AKR1B1 (HGNC Symbol)

Synonyms

ALDR1, AR

Description

Aldo-keto reductase family 1, member B1 (aldose reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Chromosome

7

Cytoband

q33

Chromosome location (bp)

134442350 - 134459284

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000085662 (version 83.38)

Entrez gene

231

UniProt

P15121 (UniProt - Evidence at protein level)

neXtProt

NX_P15121

Antibodypedia

AKR1B1 antibodies

PROTEIN BROWSER

AKR1B1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1B1-001
ENSP00000285930
ENST00000285930
P15121 [Direct mapping]
Aldose reductase
A0A024R7A8 [Target identity:100%; Query identity:100%]
Aldo-keto reductase family 1, member B1 (Aldose reductase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001894 [tissue homeostasis]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005996 [monosaccharide metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006061 [sorbitol biosynthetic process]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006950 [response to stress]
GO:0008202 [steroid metabolic process]
GO:0009055 [electron carrier activity]
GO:0009414 [response to water deprivation]
GO:0010033 [response to organic substance]
GO:0016491 [oxidoreductase activity]
GO:0018931 [naphthalene metabolic process]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032838 [cell projection cytoplasm]
GO:0033010 [paranodal junction]
GO:0042415 [norepinephrine metabolic process]
GO:0042629 [mast cell granule]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043795 [glyceraldehyde oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0046370 [fructose biosynthetic process]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0072061 [inner medullary collecting duct development]
GO:0097066 [response to thyroid hormone]
GO:0097238 [cellular response to methylglyoxal]
GO:0097454 [Schwann cell microvillus]
GO:1901653 [cellular response to peptide]
Show all
316 aa
35.9 kDa
No 0

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