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AKR1B1

GENERAL INFORMATION

Gene name

 AKR1B1

Gene description

 Aldo-keto reductase family 1, member B1 (aldose reductase)

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (adrenal gland)
FANTOM5:Tissue enriched (seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in adrenal gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA026425 , HPA052751 , CAB027391 , CAB047353
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (seminal vesicle)

GENE INFORMATION

Gene name

 AKR1B1 (HGNC Symbol)

Synonyms

 ALDR1, AR

Description

 Aldo-keto reductase family 1, member B1 (aldose reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 134442350 - 134459284

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085662 (version 83.38)

Entrez gene

 231

UniProt

 P15121 (UniProt - Evidence at protein level)

neXtProt

 NX_P15121

Antibodypedia

 AKR1B1 antibodies

PROTEIN BROWSER
AKR1B1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1B1-001
ENSP00000285930
ENST00000285930
P15121 [Direct mapping]
Aldose reductase
A0A024R7A8 [Target identity:100%; Query identity:100%]
Aldo-keto reductase family 1, member B1 (Aldose reductase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001894 [tissue homeostasis]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005996 [monosaccharide metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006061 [sorbitol biosynthetic process]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006950 [response to stress]
GO:0008202 [steroid metabolic process]
GO:0009055 [electron carrier activity]
GO:0009414 [response to water deprivation]
GO:0010033 [response to organic substance]
GO:0016491 [oxidoreductase activity]
GO:0018931 [naphthalene metabolic process]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032838 [cell projection cytoplasm]
GO:0033010 [paranodal junction]
GO:0042415 [norepinephrine metabolic process]
GO:0042629 [mast cell granule]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043795 [glyceraldehyde oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0046370 [fructose biosynthetic process]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0072061 [inner medullary collecting duct development]
GO:0097066 [response to thyroid hormone]
GO:0097238 [cellular response to methylglyoxal]
GO:0097454 [Schwann cell microvillus]
GO:1901653 [cellular response to peptide]
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 316 aa
35.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.