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CTTN

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GENERAL INFORMATION

Gene name

 CTTN

Gene description

 Cortactin

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the Golgi apparatus & vesicles.

RNA cell category

 Cell line enhanced (A-431)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported), Cytosol (approved)

Additional location

 In addition localized to the Golgi apparatus (approved), Vesicles (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA057242
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the Golgi apparatus & vesicles.

Main location

 Plasma membrane (supported), Cytosol (approved)

Additional location

 Golgi apparatus (approved), Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057242 A-431 Vesicles
Plasma membrane
HPA057242 RT4 Golgi apparatus
Vesicles
Cytosol
HPA057242 U-2 OS Vesicles
Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 CTTN (HGNC Symbol)

Synonyms

 EMS1

Description

 Cortactin (HGNC Symbol)

Entrez gene summary

 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 q13.3

Chromosome location (bp)

 70398404 - 70436584

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085733 (version 83.38)

Entrez gene

 2017

UniProt

 Q14247 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14247

Antibodypedia

 CTTN antibodies

PROTEIN BROWSER
CTTN-001
CTTN-002
CTTN-008
CTTN-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTTN-001
ENSP00000317189
ENST00000346329
Q14247 [Direct mapping]
Src substrate cortactin
A0A024R5M3 [Target identity:100%; Query identity:100%]
Cortactin, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097581 [lamellipodium organization]
Show all
 513 aa
57.5 kDa 		No 0
CTTN-002
ENSP00000301843
ENST00000301843
Q14247 [Direct mapping]
Src substrate cortactin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097581 [lamellipodium organization]
Show all
 550 aa
61.6 kDa 		No 0
CTTN-008
ENSP00000365745
ENST00000376561
Q14247 [Direct mapping]
Src substrate cortactin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097062 [dendritic spine maintenance]
GO:0097581 [lamellipodium organization]
GO:1903146 [regulation of mitophagy]
GO:1990023 [mitotic spindle midzone]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 634 aa
71 kDa 		No 0
CTTN-016
ENSP00000431421
ENST00000529736
H0YCD9 [Direct mapping]
Src substrate cortactin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030041 [actin filament polymerization]
Show all
 265 aa
29.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.