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CTTN

GENERAL INFORMATION

Gene name

 CTTN

Gene description

 Cortactin

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA057242 , CAB011235
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057242
CAB011235

GENE INFORMATION

Gene name

 CTTN (HGNC Symbol)

Synonyms

 EMS1

Description

 Cortactin (HGNC Symbol)

Entrez gene summary

 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Chromosome

 11

Cytoband

 q13.3

Chromosome location (bp)

 70398404 - 70436584

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000085733 (version 83.38)

Entrez gene

 2017

UniProt

 Q14247 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14247

Antibodypedia

 CTTN antibodies

PROTEIN BROWSER
CTTN-001
CTTN-002
CTTN-008
CTTN-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTTN-001
ENSP00000317189
ENST00000346329
Q14247 [Direct mapping]
Src substrate cortactin
A0A024R5M3 [Target identity:100%; Query identity:100%]
Cortactin, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097581 [lamellipodium organization]
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 513 aa
57.5 kDa 		No 0
CTTN-002
ENSP00000301843
ENST00000301843
Q14247 [Direct mapping]
Src substrate cortactin
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097581 [lamellipodium organization]
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 550 aa
61.6 kDa 		No 0
CTTN-008
ENSP00000365745
ENST00000376561
Q14247 [Direct mapping]
Src substrate cortactin
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005905 [coated pit]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030426 [growth cone]
GO:0030516 [regulation of axon extension]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030863 [cortical cytoskeleton]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043197 [dendritic spine]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0048041 [focal adhesion assembly]
GO:0048812 [neuron projection morphogenesis]
GO:0048870 [cell motility]
GO:0070062 [extracellular exosome]
GO:0097062 [dendritic spine maintenance]
GO:0097581 [lamellipodium organization]
GO:1903146 [regulation of mitophagy]
GO:1990023 [mitotic spindle midzone]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 634 aa
71 kDa 		No 0
CTTN-016
ENSP00000431421
ENST00000529736
H0YCD9 [Direct mapping]
Src substrate cortactin
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0030041 [actin filament polymerization]
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 265 aa
29.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.