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CHMP5

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GENERAL INFORMATION

Gene name

 CHMP5

Gene description

 Charged multivesicular body protein 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol, microtubules & midbody.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved), Midbody (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB033874
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol, microtubules & midbody.

Main location

 Microtubules (approved), Midbody (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB033874 A-431 Nucleoplasm
Microtubules
Cytosol
CAB033874 U-2 OS Midbody Intensity Intensity
Cytosol
CAB033874 U-251 MG Microtubules
Cytosol

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

GENE INFORMATION

Gene name

 CHMP5 (HGNC Symbol)

Synonyms

 C9orf83, CGI-34, HSPC177, SNF7DC2, Vps60

Description

 Charged multivesicular body protein 5 (HGNC Symbol)

Entrez gene summary

 CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 33264879 - 33282069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086065 (version 83.38)

Entrez gene

 51510

UniProt

 Q9NZZ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZZ3

Antibodypedia

 CHMP5 antibodies

PROTEIN BROWSER
CHMP5-001
CHMP5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP5-001
ENSP00000223500
ENST00000223500
Q9NZZ3 [Direct mapping]
Charged multivesicular body protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0001919 [regulation of receptor recycling]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007040 [lysosome organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0008333 [endosome to lysosome transport]
GO:0010008 [endosome membrane]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0046755 [viral budding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:1901673 [regulation of mitotic spindle assembly]
Show all
 219 aa
24.6 kDa 		No 0
CHMP5-201
ENSP00000442725
ENST00000419016
Q9NZZ3 [Direct mapping]
Charged multivesicular body protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010008 [endosome membrane]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0046755 [viral budding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071985 [multivesicular body sorting pathway]
GO:1901673 [regulation of mitotic spindle assembly]
Show all
 171 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.