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MMP2

GENERAL INFORMATION

Gene name

 MMP2

Gene description

 Matrix metallopeptidase 2

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, BJ hTERT+, U-138 MG, U-87 MG)
HPA (normal tissue):Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in respiratory epithelia and placenta as well as endothelial and stromal cells in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001939 , CAB002788
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
HPA001939
CAB002788

GENE INFORMATION

Gene name

 MMP2 (HGNC Symbol)

Synonyms

 CLG4, CLG4A, TBE-1

Description

 Matrix metallopeptidase 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

 16

Cytoband

 q12.2

Chromosome location (bp)

 55389700 - 55506691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087245 (version 83.38)

Entrez gene

 4313

UniProt

 P08253 (UniProt - Evidence at protein level)

neXtProt

 NX_P08253

Antibodypedia

 MMP2 antibodies

PROTEIN BROWSER
MMP2-001
MMP2-002
MMP2-003
MMP2-004
MMP2-006
MMP2-007
MMP2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP2-001
ENSP00000219070
ENST00000219070
P08253 [Direct mapping]
72 kDa type IV collagenase PEX
A0A024R6R4 [Target identity:100%; Query identity:100%]
Matrix metallopeptidase 2 (Gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0001955 [blood vessel maturation]
GO:0001957 [intramembranous ossification]
GO:0004222 [metalloendopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007411 [axon guidance]
GO:0007566 [embryo implantation]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030017 [sarcomere]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
GO:0044267 [cellular protein metabolic process]
GO:0045089 [positive regulation of innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048705 [skeletal system morphogenesis]
GO:0060325 [face morphogenesis]
GO:0060346 [bone trabecula formation]
GO:0071230 [cellular response to amino acid stimulus]
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 660 aa
73.9 kDa 		Yes 0
MMP2-002
ENSP00000444143
ENST00000543485
P08253 [Direct mapping]
72 kDa type IV collagenase PEX
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004222 [metalloendopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
GO:0007411 [axon guidance]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
GO:0044267 [cellular protein metabolic process]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 584 aa
65.8 kDa 		No 0
MMP2-003
ENSP00000394237
ENST00000437642
P08253 [Direct mapping]
72 kDa type IV collagenase PEX
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004222 [metalloendopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
GO:0007411 [axon guidance]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
GO:0044267 [cellular protein metabolic process]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 610 aa
68.8 kDa 		No 0
MMP2-004
ENSP00000456096
ENST00000564864
H3BR66 [Direct mapping]
72 kDa type IV collagenase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
 201 aa
22.9 kDa 		No 0
MMP2-006
ENSP00000456518
ENST00000570283
H3BS34 [Direct mapping]
72 kDa type IV collagenase
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
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 252 aa
28.3 kDa 		No 0
MMP2-007
ENSP00000457949
ENST00000568715
H3BV48 [Direct mapping]
72 kDa type IV collagenase
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
 118 aa
13.6 kDa 		No 0
MMP2-008
ENSP00000461421
ENST00000570308
P08253 [Direct mapping]
72 kDa type IV collagenase PEX
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004222 [metalloendopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
GO:0007411 [axon guidance]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
GO:0044267 [cellular protein metabolic process]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 584 aa
65.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.