Tissue expression of MMP2 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MMP2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MMP2
Gene description	Matrix metallopeptidase 2
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder)
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in respiratory epithelia and placenta as well as endothelial and stromal cells in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA001939 , CAB002788
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

N/A

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MMP2 (HGNC Symbol)
Synonyms	CLG4, CLG4A, TBE-1
Description	Matrix metallopeptidase 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	55389700 - 55506691
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087245 (version 83.38)
Entrez gene	4313
UniProt	P08253 (UniProt - Evidence at protein level)
neXtProt	NX_P08253
Antibodypedia	MMP2 antibodies

PROTEIN BROWSER

MMP2-001	MMP2-002	MMP2-003	MMP2-004	MMP2-006	MMP2-007	MMP2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMP2-001 ENSP00000219070 ENST00000219070	P08253 [Direct mapping] 72 kDa type IV collagenase PEX A0A024R6R4 [Target identity:100%; Query identity:100%] Matrix metallopeptidase 2 (Gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0001955 [blood vessel maturation] GO:0001957 [intramembranous ossification] GO:0004222 [metalloendopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007411 [axon guidance] GO:0007566 [embryo implantation] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030017 [sarcomere] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0044267 [cellular protein metabolic process] GO:0045089 [positive regulation of innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0048705 [skeletal system morphogenesis] GO:0060325 [face morphogenesis] GO:0060346 [bone trabecula formation] GO:0071230 [cellular response to amino acid stimulus] Show all	660 aa 73.9 kDa	Yes	0
MMP2-002 ENSP00000444143 ENST00000543485	P08253 [Direct mapping] 72 kDa type IV collagenase PEX Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004222 [metalloendopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0007411 [axon guidance] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0044267 [cellular protein metabolic process] GO:0048013 [ephrin receptor signaling pathway] Show all	584 aa 65.8 kDa	No	0
MMP2-003 ENSP00000394237 ENST00000437642	P08253 [Direct mapping] 72 kDa type IV collagenase PEX Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004222 [metalloendopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0007411 [axon guidance] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0044267 [cellular protein metabolic process] GO:0048013 [ephrin receptor signaling pathway] Show all	610 aa 68.8 kDa	No	0
MMP2-004 ENSP00000456096 ENST00000564864	H3BR66 [Direct mapping] 72 kDa type IV collagenase Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	201 aa 22.9 kDa	No	0
MMP2-006 ENSP00000456518 ENST00000570283	H3BS34 [Direct mapping] 72 kDa type IV collagenase Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	252 aa 28.3 kDa	No	0
MMP2-007 ENSP00000457949 ENST00000568715	H3BV48 [Direct mapping] 72 kDa type IV collagenase Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	118 aa 13.6 kDa	No	0
MMP2-008 ENSP00000461421 ENST00000570308	P08253 [Direct mapping] 72 kDa type IV collagenase PEX Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004222 [metalloendopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0007411 [axon guidance] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0044267 [cellular protein metabolic process] GO:0048013 [ephrin receptor signaling pathway] Show all	584 aa 65.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.