Fields »
ABOUT
HELP
BLOG
SIGLEC1

GENERAL INFORMATION

Gene name

 SIGLEC1

Gene description

 Sialic acid binding Ig-like lectin 1, sialoadhesin

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (THP-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in macrophages in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
HPA053457
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001
Testis cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053457

GENE INFORMATION

Gene name

 SIGLEC1 (HGNC Symbol)

Synonyms

 CD169, dJ1009E24.1, FLJ00051, FLJ00055, FLJ00073, FLJ32150, sialoadhesin, SIGLEC-1, SN

Description

 Sialic acid binding Ig-like lectin 1, sialoadhesin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3686970 - 3707128

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088827 (version 83.38)

Entrez gene

 6614

UniProt

 Q9BZZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZZ2

Antibodypedia

 SIGLEC1 antibodies

PROTEIN BROWSER
SIGLEC1-001
SIGLEC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIGLEC1-001
ENSP00000341141
ENST00000344754
Q9BZZ2 [Direct mapping]
Sialoadhesin
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0006954 [inflammatory response]
GO:0007160 [cell-matrix adhesion]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030246 [carbohydrate binding]
GO:0070234 [positive regulation of T cell apoptotic process]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 1709 aa
182.6 kDa 		Yes 1
SIGLEC1-002
ENSP00000395778
ENST00000419548
H7C0M6 [Direct mapping]
Sialoadhesin
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 463 aa
48.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.