Tissue expression of SIGLEC1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SIGLEC1
Gene description	Sialic acid binding Ig-like lectin 1, sialoadhesin
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enriched (lymph node)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in macrophages in several tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA053457
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lymph node)

GENE INFORMATION
Gene name	SIGLEC1 (HGNC Symbol)
Synonyms	CD169, dJ1009E24.1, FLJ00051, FLJ00055, FLJ00073, FLJ32150, sialoadhesin, SIGLEC-1, SN
Description	Sialic acid binding Ig-like lectin 1, sialoadhesin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3686970 - 3707128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088827 (version 83.38)
Entrez gene	6614
UniProt	Q9BZZ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZZ2
Antibodypedia	SIGLEC1 antibodies

PROTEIN BROWSER

SIGLEC1-001	SIGLEC1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIGLEC1-001 ENSP00000341141 ENST00000344754	Q9BZZ2 [Direct mapping] Sialoadhesin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0006954 [inflammatory response] GO:0007160 [cell-matrix adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030246 [carbohydrate binding] GO:0070234 [positive regulation of T cell apoptotic process] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	1709 aa 182.6 kDa	Yes	1
SIGLEC1-002 ENSP00000395778 ENST00000419548	H7C0M6 [Direct mapping] Sialoadhesin Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	463 aa 48.4 kDa	No	0