Cell atlas - CHGB - The Human Protein Atlas

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CHGB

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CHGB
Gene description	Chromogranin B
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Group enriched (SH-SY5Y, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA008759 , HPA012602
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SH-SY5Y, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012602	SH-SY5Y	Vesicles
	HPA008759	SH-SY5Y	Vesicles

GENE INFORMATION
Gene name	CHGB (HGNC Symbol)
Synonyms	SCG1, SgI
Description	Chromogranin B (HGNC Symbol)
Entrez gene summary	This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Chromosome	20
Cytoband	p12.3
Chromosome location (bp)	5911430 - 5925361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089199 (version 83.38)
Entrez gene	1114
UniProt	P05060 (UniProt - Evidence at protein level)
neXtProt	NX_P05060
Antibodypedia	CHGB antibodies

PROTEIN BROWSER

CHGB-001	CHGB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHGB-001 ENSP00000368244 ENST00000378961	P05060 [Direct mapping] Secretogranin-1 PE-11 GAWK peptide CCB peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030141 [secretory granule] Show all	677 aa 78.3 kDa	Yes	0
CHGB-002 ENSP00000416643 ENST00000455042	A0A0A0MT66 [Direct mapping] Secretogranin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	289 aa 32.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.