Malignant carcinoids displayed strong immunoreactivity while fractions of cells in for example lung and pancreatic cancers were moderately stained. Malignant cells in general were weakly stained or negative.
In cancer cells, strong staining was observed in the cytoplasm of carcinoids. Cancer cells in general were negative.
CHGB (HGNC Symbol)
Chromogranin B (HGNC Symbol)
Entrez gene summary
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]