Expression of CHGB in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CHGB
Gene description	Chromogranin B
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adrenal medulla, islets of Langerhans, enteroendocrine cells and subsets of neuronal cells the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA008759 , HPA012602 , CAB009403
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and pancreatic cancer (favourable).
Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008759	HPA012602	CAB009403

GENE INFORMATION
Gene name	CHGB (HGNC Symbol)
Synonyms	SCG1, SgI
Description	Chromogranin B (HGNC Symbol)
Entrez gene summary	This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Chromosome	20
Cytoband	p12.3
Chromosome location (bp)	5911430 - 5925361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089199 (version 83.38)
Entrez gene	1114
UniProt	P05060 (UniProt - Evidence at protein level)
neXtProt	NX_P05060
Antibodypedia	CHGB antibodies

PROTEIN BROWSER

CHGB-001	CHGB-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHGB-001 ENSP00000368244 ENST00000378961	P05060 [Direct mapping] Secretogranin-1 PE-11 GAWK peptide CCB peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0030141 [secretory granule] Show all	677 aa 78.3 kDa	Yes	0
CHGB-002 ENSP00000416643 ENST00000455042	A0A0A0MT66 [Direct mapping] Secretogranin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030141 [secretory granule] Show all	289 aa 32.4 kDa	No	0