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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CHGB
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TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CHGB

Gene description

Chromogranin B

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Group enriched (adrenal gland, cerebellum, pituitary gland)
FANTOM5:Group enriched (cerebellum, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in adrenal medulla, islets of Langerhans, enteroendocrine cells and subsets of neuronal cells the CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA008759 , HPA012602 , CAB009403
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebellum, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, pituitary gland)

GENE INFORMATION

Gene name

CHGB (HGNC Symbol)

Synonyms

SCG1, SgI

Description

Chromogranin B (HGNC Symbol)

Entrez gene summary

This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

Chromosome

20

Cytoband

p12.3

Chromosome location (bp)

5911430 - 5925361

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089199 (version 83.38)

Entrez gene

1114

UniProt

P05060 (UniProt - Evidence at protein level)

neXtProt

NX_P05060

Antibodypedia

CHGB antibodies

PROTEIN BROWSER

CHGB-001
CHGB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHGB-001
ENSP00000368244
ENST00000378961
P05060 [Direct mapping]
Secretogranin-1 PE-11 GAWK peptide CCB peptide
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0030141 [secretory granule]
Show all
677 aa
78.3 kDa
Yes 0
CHGB-002
ENSP00000416643
ENST00000455042
A0A0A0MT66 [Direct mapping]
Secretogranin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030141 [secretory granule]
Show all
289 aa
32.4 kDa
No 0

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