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CHGB

GENERAL INFORMATION

Gene name

 CHGB

Gene description

 Chromogranin B

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Group enriched (adrenal gland, cerebellum, pituitary gland)
FANTOM5:Group enriched (cerebellum, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adrenal medulla, islets of Langerhans, enteroendocrine cells and subsets of neuronal cells the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008759 , HPA012602 , CAB009403
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebellum, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, pituitary gland)

GENE INFORMATION

Gene name

 CHGB (HGNC Symbol)

Synonyms

 SCG1, SgI

Description

 Chromogranin B (HGNC Symbol)

Entrez gene summary

 This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

Chromosome

 20

Cytoband

 p12.3

Chromosome location (bp)

 5911430 - 5925361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089199 (version 83.38)

Entrez gene

 1114

UniProt

 P05060 (UniProt - Evidence at protein level)

neXtProt

 NX_P05060

Antibodypedia

 CHGB antibodies

PROTEIN BROWSER
CHGB-001
CHGB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHGB-001
ENSP00000368244
ENST00000378961
P05060 [Direct mapping]
Secretogranin-1 PE-11 GAWK peptide CCB peptide
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0030141 [secretory granule]
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 677 aa
78.3 kDa 		Yes 0
CHGB-002
ENSP00000416643
ENST00000455042
A0A0A0MT66 [Direct mapping]
Secretogranin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030141 [secretory granule]
Show all
 289 aa
32.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.