Cell atlas - PDCD7 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PDCD7
Gene description	Programmed cell death 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Nucleoli (approved)
Mouse	Localized to the Plasma membrane in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049388
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleoli.

Main location

Plasma membrane (approved)

Additional location

Nucleoli (approved)


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Antibody	Cell line	Location
HPA049388	A-431	Nucleoli
HPA049388	A-431	Plasma membrane
HPA049388	U-2 OS	Plasma membrane
HPA049388	U-251 MG	Nucleoli
HPA049388	U-251 MG	Plasma membrane

MOUSE CELLS

Main location

Plasma membrane

Additional location

Nucleoli

Mouse gene

ENSMUSG00000041837 (version 83)


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Thumbnail	Antibody	Cell line	Location
	HPA049388	NIH 3T3	Nucleoli
	HPA049388	NIH 3T3	Plasma membrane

GENE INFORMATION
Gene name	PDCD7 (HGNC Symbol)
Synonyms	ES18, HES18
Description	Programmed cell death 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65117379 - 65133836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090470 (version 83.38)
Entrez gene	10081
UniProt	Q8N8D1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8D1
Antibodypedia	PDCD7 antibodies

PROTEIN BROWSER

PDCD7-001	PDCD7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCD7-001 ENSP00000204549 ENST00000204549	Q8N8D1 [Direct mapping] Programmed cell death protein 7 Q6IEG3 [Target identity:100%; Query identity:100%] Programmed cell death 7, isoform CRA_a; U11/U12 snRNP 59K Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0006915 [apoptotic process] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0051384 [response to glucocorticoid] GO:0070234 [positive regulation of T cell apoptotic process] GO:2001235 [positive regulation of apoptotic signaling pathway] Show all	485 aa 54.7 kDa	No	0
PDCD7-005 ENSP00000457053 ENST00000560313	H3BT73 [Direct mapping] Programmed cell death protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 12 kDa	No	0