Expression of PDCD7 in cancer - Summary - The Human Protein Atlas

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PDCD7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDCD7
Gene description	Programmed cell death 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Sub cellular location is contradicted by external data.
Reliability score	Approved based on 1 antibody. HPA049388
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049388

GENE INFORMATION
Gene name	PDCD7 (HGNC Symbol)
Synonyms	ES18, HES18
Description	Programmed cell death 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65117379 - 65133836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090470 (version 83.38)
Entrez gene	10081
UniProt	Q8N8D1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8D1
Antibodypedia	PDCD7 antibodies

PROTEIN BROWSER

PDCD7-001	PDCD7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCD7-001 ENSP00000204549 ENST00000204549	Q8N8D1 [Direct mapping] Programmed cell death protein 7 Q6IEG3 [Target identity:100%; Query identity:100%] Programmed cell death 7, isoform CRA_a; U11/U12 snRNP 59K Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0006915 [apoptotic process] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0051384 [response to glucocorticoid] GO:0070234 [positive regulation of T cell apoptotic process] GO:2001235 [positive regulation of apoptotic signaling pathway] Show all	485 aa 54.7 kDa	No	0
PDCD7-005 ENSP00000457053 ENST00000560313	H3BT73 [Direct mapping] Programmed cell death protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.