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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TF

Gene description

Transferrin

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma with cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA001527 , HPA005692 , CAB009538
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA001527
HPA005692
CAB009538

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of colorectal, prostate, endometrial, lung, testis, urothelial and hepatocellular cancers showed moderate cytoplasmic immunoreactivity. Remaining cancers were weakly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic immunoreactivity was displayed in few cases of a majority of cancers. Strong extracellular positivity was observed in all cancer tissues. Lymphomas, gliomas and head and neck, thyroid, ovarian and prostate cancers were mainly negaitve.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Distinct positivity was observed in plasma. Rare cases in several different cancer types showed weak to moderate cytoplasmic staining.

GENE INFORMATION

Gene name

TF (HGNC Symbol)

Synonyms

PRO1557, PRO2086

Description

Transferrin (HGNC Symbol)

Entrez gene summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

133745956 - 133779006

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091513 (version 83.38)

Entrez gene

7018

UniProt

P02787 (UniProt - Evidence at protein level)

neXtProt

NX_P02787

Antibodypedia

TF antibodies

PROTEIN BROWSER

TF-001
TF-008
TF-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TF-001
ENSP00000385834
ENST00000402696
P02787 [Direct mapping]
Serotransferrin
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005905 [coated pit]
GO:0006826 [iron ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0007596 [blood coagulation]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015091 [ferric iron transmembrane transporter activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031647 [regulation of protein stability]
GO:0031982 [vesicle]
GO:0033572 [transferrin transport]
GO:0034774 [secretory granule lumen]
GO:0045178 [basal part of cell]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055072 [iron ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071281 [cellular response to iron ion]
GO:0072562 [blood microparticle]
GO:0097460 [ferrous iron import into cell]
GO:1990459 [transferrin receptor binding]
GO:1990712 [HFE-transferrin receptor complex]
Show all
698 aa
77.1 kDa
Yes 0
TF-008
ENSP00000419338
ENST00000482271
C9JVG0 [Direct mapping]
Serotransferrin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
134 aa
14.7 kDa
No 0
TF-016
ENSP00000417468
ENST00000466911
C9JB55 [Direct mapping]
Serotransferrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
76 aa
8.1 kDa
No 0

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