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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TF

Gene description

Transferrin

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma with cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA001527 , HPA005692 , CAB009538
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

TF (HGNC Symbol)

Synonyms

PRO1557, PRO2086

Description

Transferrin (HGNC Symbol)

Entrez gene summary

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

133745956 - 133779006

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091513 (version 83.38)

Entrez gene

7018

UniProt

P02787 (UniProt - Evidence at protein level)

neXtProt

NX_P02787

Antibodypedia

TF antibodies

PROTEIN BROWSER

TF-001
TF-008
TF-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TF-001
ENSP00000385834
ENST00000402696
P02787 [Direct mapping]
Serotransferrin
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005905 [coated pit]
GO:0006826 [iron ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0007596 [blood coagulation]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015091 [ferric iron transmembrane transporter activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016324 [apical plasma membrane]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031647 [regulation of protein stability]
GO:0031982 [vesicle]
GO:0033572 [transferrin transport]
GO:0034774 [secretory granule lumen]
GO:0045178 [basal part of cell]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055072 [iron ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071281 [cellular response to iron ion]
GO:0072562 [blood microparticle]
GO:0097460 [ferrous iron import into cell]
GO:1990459 [transferrin receptor binding]
GO:1990712 [HFE-transferrin receptor complex]
Show all
698 aa
77.1 kDa
Yes 0
TF-008
ENSP00000419338
ENST00000482271
C9JVG0 [Direct mapping]
Serotransferrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
134 aa
14.7 kDa
No 0
TF-016
ENSP00000417468
ENST00000466911
C9JB55 [Direct mapping]
Serotransferrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
76 aa
8.1 kDa
No 0

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