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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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APOH
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

APOH

Gene description

Apolipoprotein H (beta-2-glycoprotein I)

Protein class

Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 3 antibodies.
HPA001654 , HPA003732 , CAB022214
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001654
HPA003732
CAB022214

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies showed weak to moderate cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few cases of malignant carcinoids, liver and renal cancers exhibited weak to moderate cytoplasmic immunoreactivity. Malignant cells in general were negative.

GENE INFORMATION

Gene name

APOH (HGNC Symbol)

Synonyms

B2G1, BG

Description

Apolipoprotein H (beta-2-glycoprotein I) (HGNC Symbol)

Entrez gene summary

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.2

Chromosome location (bp)

66212033 - 66256525

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091583 (version 83.38)

Entrez gene

350

UniProt

P02749 (UniProt - Evidence at protein level)

neXtProt

NX_P02749

Antibodypedia

APOH antibodies

PROTEIN BROWSER

APOH-001
APOH-002
APOH-003
APOH-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOH-001
ENSP00000205948
ENST00000205948
P02749 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006641 [triglyceride metabolic process]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0016525 [negative regulation of angiogenesis]
GO:0030193 [regulation of blood coagulation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030195 [negative regulation of blood coagulation]
GO:0031012 [extracellular matrix]
GO:0031100 [organ regeneration]
GO:0031639 [plasminogen activation]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0034014 [response to triglyceride]
GO:0034197 [triglyceride transport]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0042627 [chylomicron]
GO:0042802 [identical protein binding]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051917 [regulation of fibrinolysis]
GO:0051918 [negative regulation of fibrinolysis]
GO:0060230 [lipoprotein lipase activator activity]
GO:0060268 [negative regulation of respiratory burst]
GO:0070062 [extracellular exosome]
Show all
345 aa
38.3 kDa
Yes 0
APOH-002
ENSP00000463553
ENST00000581797
J3QLI0 [Direct mapping]
Beta-2-glycoprotein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
200 aa
22.2 kDa
No 0
APOH-003
ENSP00000464301
ENST00000577982
J3QRN2 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
181 aa
19.9 kDa
Yes 0
APOH-004
ENSP00000462260
ENST00000585162
J3KS17 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
104 aa
11.6 kDa
No 0

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