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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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APOH
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

APOH

Gene description

Apolipoprotein H (beta-2-glycoprotein I)

Protein class

Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Selective positivity in plasma.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 3 antibodies.
HPA001654 , HPA003732 , CAB022214
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

APOH (HGNC Symbol)

Synonyms

B2G1, BG

Description

Apolipoprotein H (beta-2-glycoprotein I) (HGNC Symbol)

Entrez gene summary

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.2

Chromosome location (bp)

66212033 - 66256525

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091583 (version 83.38)

Entrez gene

350

UniProt

P02749 (UniProt - Evidence at protein level)

neXtProt

NX_P02749

Antibodypedia

APOH antibodies

PROTEIN BROWSER

APOH-001
APOH-002
APOH-003
APOH-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOH-001
ENSP00000205948
ENST00000205948
P02749 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006641 [triglyceride metabolic process]
GO:0007568 [aging]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0008201 [heparin binding]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0016525 [negative regulation of angiogenesis]
GO:0030193 [regulation of blood coagulation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030195 [negative regulation of blood coagulation]
GO:0031012 [extracellular matrix]
GO:0031100 [organ regeneration]
GO:0031639 [plasminogen activation]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0034014 [response to triglyceride]
GO:0034197 [triglyceride transport]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034392 [negative regulation of smooth muscle cell apoptotic process]
GO:0042627 [chylomicron]
GO:0042802 [identical protein binding]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051917 [regulation of fibrinolysis]
GO:0051918 [negative regulation of fibrinolysis]
GO:0060230 [lipoprotein lipase activator activity]
GO:0060268 [negative regulation of respiratory burst]
GO:0070062 [extracellular exosome]
Show all
345 aa
38.3 kDa
Yes 0
APOH-002
ENSP00000463553
ENST00000581797
J3QLI0 [Direct mapping]
Beta-2-glycoprotein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
200 aa
22.2 kDa
No 0
APOH-003
ENSP00000464301
ENST00000577982
J3QRN2 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
181 aa
19.9 kDa
Yes 0
APOH-004
ENSP00000462260
ENST00000585162
J3KS17 [Direct mapping]
Beta-2-glycoprotein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
104 aa
11.6 kDa
No 0

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