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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000784 [nuclear chromosome, telomeric region] GO:0000785 [chromatin] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006334 [nucleosome assembly] GO:0006342 [chromatin silencing] GO:0007420 [brain development] GO:0007549 [dosage compensation] GO:0016568 [chromatin modification] GO:0031490 [chromatin DNA binding] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]