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Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).
Most cancer cells exhibited weak to moderate nuclear staining. Fractions of gliomas, endometrial, pancreatic and prostate cancer were strongly stained. Melanomas, lymphomas, skin, testis, liver and gastric cancers were negative in most cases.
Cancer cells showed weak to moderate nuclear staining. Gliomas along with occasional cases of breast and urothelial cancers showed strong positivity.
GENE INFORMATION
Gene name
H2AFY2 (HGNC Symbol)
Synonyms
macroH2A2
Description
H2A histone family, member Y2 (HGNC Symbol)
Entrez gene summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000784 [nuclear chromosome, telomeric region] GO:0000785 [chromatin] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001740 [Barr body] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006334 [nucleosome assembly] GO:0006342 [chromatin silencing] GO:0007420 [brain development] GO:0007549 [dosage compensation] GO:0016568 [chromatin modification] GO:0031490 [chromatin DNA binding] GO:0035098 [ESC/E(Z) complex] GO:0044212 [transcription regulatory region DNA binding] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] GO:0071169 [establishment of protein localization to chromatin] GO:1901837 [negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter]