Most malignant cells showed moderate to strong nuclear and occasional cytoplasmic immunoreactivity. Several cases of renal and hepatocellular carcinomas along with a few cases of lymphomas and prostate cancers were weakly stained.
PHF5A (HGNC Symbol)
bK223H9.2, INI, MGC1346, Rds3, SAP14b, SF3b14b, SF3B7
PHD finger protein 5A (HGNC Symbol)
Entrez gene summary
This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]