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PHF5A

GENERAL INFORMATION

Gene name

 PHF5A

Gene description

 PHD finger protein 5A

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA028885
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PHF5A (HGNC Symbol)

Synonyms

 bK223H9.2, INI, MGC1346, Rds3, SAP14b, SF3b14b, SF3B7

Description

 PHD finger protein 5A (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 41459717 - 41468725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100410 (version 83.38)

Entrez gene

 84844

UniProt

 Q7RTV0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7RTV0

Antibodypedia

 PHF5A antibodies

PROTEIN BROWSER
PHF5A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHF5A-001
ENSP00000216252
ENST00000216252
Q7RTV0 [Direct mapping]
PHD finger-like domain-containing protein 5A
A0A024R1U2 [Target identity:100%; Query identity:100%]
PHD finger protein 5A, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0006351 [transcription, DNA-templated]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
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 110 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.