Cell atlas - PYGL - The Human Protein Atlas

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PYGL

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PYGL
Gene description	Phosphorylase, glycogen, liver
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA000962 , HPA004119
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol.

Main location

Plasma membrane (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004119	A-431	Plasma membrane
	HPA004119	A-431	Cytosol
	HPA004119	U-2 OS	Plasma membrane
	HPA004119	U-2 OS	Cytosol
	HPA004119	U-251 MG	Plasma membrane
	HPA004119	U-251 MG	Cytosol
	HPA000962	A-431	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA000962	U-2 OS	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA000962	U-251 MG	Nucleoplasm
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	PYGL
Synonyms
Description	Phosphorylase, glycogen, liver (HGNC Symbol)
Entrez gene summary	This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
Chromosome	14
Cytoband	q22.1
Chromosome location (bp)	50857891 - 50944736
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100504 (version 83.38)
Entrez gene	5836
UniProt	P06737 (UniProt - Evidence at protein level)
neXtProt	NX_P06737
Antibodypedia	PYGL antibodies

PROTEIN BROWSER

PYGL-001	PYGL-002	PYGL-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PYGL-001 ENSP00000216392 ENST00000216392	P06737 [Direct mapping] Glycogen phosphorylase, liver form Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002060 [purine nucleobase binding] GO:0004645 [phosphorylase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process] GO:0008144 [drug binding] GO:0008184 [glycogen phosphorylase activity] GO:0016208 [AMP binding] GO:0019842 [vitamin binding] GO:0030170 [pyridoxal phosphate binding] GO:0030246 [carbohydrate binding] GO:0032052 [bile acid binding] GO:0042593 [glucose homeostasis] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0070266 [necroptotic process] Show all	847 aa 97.1 kDa	No	0
PYGL-002 ENSP00000443787 ENST00000544180	P06737 [Direct mapping] Glycogen phosphorylase, liver form Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002060 [purine nucleobase binding] GO:0004645 [phosphorylase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0008144 [drug binding] GO:0008184 [glycogen phosphorylase activity] GO:0016208 [AMP binding] GO:0019842 [vitamin binding] GO:0030170 [pyridoxal phosphate binding] GO:0032052 [bile acid binding] GO:0042593 [glucose homeostasis] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	813 aa 93.1 kDa	No	0
PYGL-003 ENSP00000431657 ENST00000532462	E9PK47 [Direct mapping] Alpha-1,4 glucan phosphorylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004645 [phosphorylase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005980 [glycogen catabolic process] GO:0008184 [glycogen phosphorylase activity] GO:0030170 [pyridoxal phosphate binding] Show all	819 aa 94.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.