Fields »
ABOUT
HELP
BLOG
PYGL

GENERAL INFORMATION

Gene name

 PYGL

Gene description

 Phosphorylase, glycogen, liver

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues, including, hepatocytes, subsets of cells in bone marrow and spleen.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000962 , HPA004119
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000962
HPA004119

GENE INFORMATION

Gene name

 PYGL

Synonyms

Description

 Phosphorylase, glycogen, liver (HGNC Symbol)

Entrez gene summary

 This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 50857891 - 50944736

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100504 (version 83.38)

Entrez gene

 5836

UniProt

 P06737 (UniProt - Evidence at protein level)

neXtProt

 NX_P06737

Antibodypedia

 PYGL antibodies

PROTEIN BROWSER
PYGL-001
PYGL-002
PYGL-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PYGL-001
ENSP00000216392
ENST00000216392
P06737 [Direct mapping]
Glycogen phosphorylase, liver form
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002060 [purine nucleobase binding]
GO:0004645 [phosphorylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process]
GO:0008144 [drug binding]
GO:0008184 [glycogen phosphorylase activity]
GO:0016208 [AMP binding]
GO:0019842 [vitamin binding]
GO:0030170 [pyridoxal phosphate binding]
GO:0030246 [carbohydrate binding]
GO:0032052 [bile acid binding]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
Show all
 847 aa
97.1 kDa 		No 0
PYGL-002
ENSP00000443787
ENST00000544180
P06737 [Direct mapping]
Glycogen phosphorylase, liver form
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002060 [purine nucleobase binding]
GO:0004645 [phosphorylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0008144 [drug binding]
GO:0008184 [glycogen phosphorylase activity]
GO:0016208 [AMP binding]
GO:0019842 [vitamin binding]
GO:0030170 [pyridoxal phosphate binding]
GO:0032052 [bile acid binding]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 813 aa
93.1 kDa 		No 0
PYGL-003
ENSP00000431657
ENST00000532462
E9PK47 [Direct mapping]
Alpha-1,4 glucan phosphorylase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004645 [phosphorylase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0008184 [glycogen phosphorylase activity]
GO:0030170 [pyridoxal phosphate binding]
Show all
 819 aa
94.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.