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PTK6

GENERAL INFORMATION

Gene name

 PTK6

Gene description

 Protein tyrosine kinase 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Tissue enhanced (esophagus, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA036070 , HPA036071 , CAB032952
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, small intestine)

GENE INFORMATION

Gene name

 PTK6 (HGNC Symbol)

Synonyms

 BRK

Description

 Protein tyrosine kinase 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63528001 - 63537370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101213 (version 83.38)

Entrez gene

 5753

UniProt

 Q13882 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13882

Antibodypedia

 PTK6 antibodies

PROTEIN BROWSER
PTK6-001
PTK6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTK6-001
ENSP00000442460
ENST00000542869
Q13882 [Direct mapping]
Protein-tyrosine kinase 6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042503 [tyrosine phosphorylation of Stat3 protein]
GO:0042506 [tyrosine phosphorylation of Stat5 protein]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045926 [negative regulation of growth]
GO:0046777 [protein autophosphorylation]
GO:0060575 [intestinal epithelial cell differentiation]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0071300 [cellular response to retinoic acid]
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 451 aa
51.8 kDa 		No 0
PTK6-201
ENSP00000217185
ENST00000217185
Q13882 [Direct mapping]
Protein-tyrosine kinase 6
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042503 [tyrosine phosphorylation of Stat3 protein]
GO:0042506 [tyrosine phosphorylation of Stat5 protein]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0060575 [intestinal epithelial cell differentiation]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0071300 [cellular response to retinoic acid]
Show all
 134 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.