Cell atlas - ANGPT4 - The Human Protein Atlas

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ANGPT4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ANGPT4
Gene description	Angiopoietin 4
Protein class	Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (BEWO)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ANGPT4
Synonyms
Description	Angiopoietin 4 (HGNC Symbol)
Entrez gene summary	Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	869899 - 916317
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101280 (version 83.38)
Entrez gene	51378
UniProt	Q9Y264 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y264
Antibodypedia	ANGPT4 antibodies

PROTEIN BROWSER

ANGPT4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANGPT4-001 ENSP00000371347 ENST00000381922	Q9Y264 [Direct mapping] Angiopoietin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007219 [Notch signaling pathway] GO:0007596 [blood coagulation] GO:0010595 [positive regulation of endothelial cell migration] GO:0016525 [negative regulation of angiogenesis] GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity] GO:0030971 [receptor tyrosine kinase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043537 [negative regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0071456 [cellular response to hypoxia] Show all	503 aa 56.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.