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ANGPT4

GENERAL INFORMATION

Gene name

 ANGPT4

Gene description

 Angiopoietin 4

Protein class

 Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (BEWO)
HPA (normal tissue):Tissue enhanced (cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
CAB013260 , CAB013305
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB013260
CAB013305

GENE INFORMATION

Gene name

 ANGPT4

Synonyms

Description

 Angiopoietin 4 (HGNC Symbol)

Entrez gene summary

 Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 869899 - 916317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101280 (version 83.38)

Entrez gene

 51378

UniProt

 Q9Y264 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y264

Antibodypedia

 ANGPT4 antibodies

PROTEIN BROWSER
ANGPT4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANGPT4-001
ENSP00000371347
ENST00000381922
Q9Y264 [Direct mapping]
Angiopoietin-4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
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GO:0001525 [angiogenesis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007219 [Notch signaling pathway]
GO:0007596 [blood coagulation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity]
GO:0030971 [receptor tyrosine kinase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0071456 [cellular response to hypoxia]
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 503 aa
56.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.