Tissue expression of ANGPT4 - Summary - The Human Protein Atlas

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ANGPT4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ANGPT4
Gene description	Angiopoietin 4
Protein class	Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cervix, uterine)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (adipose tissue, cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. CAB013260 , CAB013305
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, cervix, uterine)

GENE INFORMATION
Gene name	ANGPT4
Synonyms
Description	Angiopoietin 4 (HGNC Symbol)
Entrez gene summary	Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	869899 - 916317
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101280 (version 83.38)
Entrez gene	51378
UniProt	Q9Y264 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y264
Antibodypedia	ANGPT4 antibodies

PROTEIN BROWSER

ANGPT4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANGPT4-001 ENSP00000371347 ENST00000381922	Q9Y264 [Direct mapping] Angiopoietin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007219 [Notch signaling pathway] GO:0007596 [blood coagulation] GO:0010595 [positive regulation of endothelial cell migration] GO:0016525 [negative regulation of angiogenesis] GO:0030297 [transmembrane receptor protein tyrosine kinase activator activity] GO:0030971 [receptor tyrosine kinase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043537 [negative regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050900 [leukocyte migration] GO:0071456 [cellular response to hypoxia] Show all	503 aa 56.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.