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NOP56

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GENERAL INFORMATION

Gene name

 NOP56

Gene description

 NOP56 ribonucleoprotein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (validated)

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA049918
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049918 HEK 293 Nucleoli fibrillar center
HPA049918 PC-3 Nucleoli fibrillar center
HPA049918 U-2 OS Nucleoli fibrillar center

GENE INFORMATION

Gene name

 NOP56 (HGNC Symbol)

Synonyms

 NOL5A, SCA36

Description

 NOP56 ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 2652145 - 2658393

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101361 (version 83.38)

Entrez gene

 10528

UniProt

 O00567 (UniProt - Evidence at protein level)

neXtProt

 NX_O00567

Antibodypedia

 NOP56 antibodies

PROTEIN BROWSER
NOP56-009
NOP56-010
NOP56-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOP56-009
ENSP00000370589
ENST00000329276
O00567 [Direct mapping]
Nucleolar protein 56
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000154 [rRNA modification]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0016020 [membrane]
GO:0030515 [snoRNA binding]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
GO:0044822 [poly(A) RNA binding]
GO:0070761 [pre-snoRNP complex]
Show all
 594 aa
66 kDa 		No 0
NOP56-010
ENSP00000403199
ENST00000415272
H0Y653 [Direct mapping]
Nucleolar protein 56
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000154 [rRNA modification]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
Show all
 219 aa
24.1 kDa 		No 0
NOP56-016
ENSP00000388497
ENST00000445139
Q5JXT2 [Direct mapping]
Nucleolar protein 56
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000154 [rRNA modification]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
Show all
 281 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.