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NOP56

GENERAL INFORMATION

Gene name

 NOP56

Gene description

 NOP56 ribonucleoprotein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049918 , CAB075757
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), endometrial cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049918
CAB075757

GENE INFORMATION

Gene name

 NOP56 (HGNC Symbol)

Synonyms

 NOL5A, SCA36

Description

 NOP56 ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jan 2009]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 2652145 - 2658393

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101361 (version 83.38)

Entrez gene

 10528

UniProt

 O00567 (UniProt - Evidence at protein level)

neXtProt

 NX_O00567

Antibodypedia

 NOP56 antibodies

PROTEIN BROWSER
NOP56-009
NOP56-010
NOP56-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOP56-009
ENSP00000370589
ENST00000329276
O00567 [Direct mapping]
Nucleolar protein 56
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000154 [rRNA modification]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0016020 [membrane]
GO:0030515 [snoRNA binding]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
GO:0044822 [poly(A) RNA binding]
GO:0070761 [pre-snoRNP complex]
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 594 aa
66 kDa 		No 0
NOP56-010
ENSP00000403199
ENST00000415272
H0Y653 [Direct mapping]
Nucleolar protein 56
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000154 [rRNA modification]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 219 aa
24.1 kDa 		No 0
NOP56-016
ENSP00000388497
ENST00000445139
Q5JXT2 [Direct mapping]
Nucleolar protein 56
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000154 [rRNA modification]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 281 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.