Cell atlas - PRPS2 - The Human Protein Atlas

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PRPS2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PRPS2
Gene description	Phosphoribosyl pyrophosphate synthetase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA067599
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067599	A-431	Vesicles
	HPA067599	HEK 293	No staining

GENE INFORMATION
Gene name	PRPS2
Synonyms
Description	Phosphoribosyl pyrophosphate synthetase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	12791355 - 12824222
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101911 (version 83.38)
Entrez gene	5634
UniProt	P11908 (UniProt - Evidence at protein level)
neXtProt	NX_P11908
Antibodypedia	PRPS2 antibodies

PROTEIN BROWSER

PRPS2-001	PRPS2-002	PRPS2-003	PRPS2-004	PRPS2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPS2-001 ENSP00000370043 ENST00000380668	P11908 [Direct mapping] Ribose-phosphate pyrophosphokinase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044249 [cellular biosynthetic process] GO:0070062 [extracellular exosome] Show all	318 aa 34.8 kDa	No	0
PRPS2-002 ENSP00000419380 ENST00000489404	D3YTJ7 [Direct mapping] Ribose-phosphate pyrophosphokinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0044249 [cellular biosynthetic process] Show all	200 aa 22.1 kDa	No	0
PRPS2-003 ENSP00000370038 ENST00000380663	A6NMS2 [Direct mapping] Ribose-phosphate pyrophosphokinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	147 aa 16.1 kDa	No	0
PRPS2-004 ENSP00000381504 ENST00000398491	P11908 [Direct mapping] Ribose-phosphate pyrophosphokinase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0002189 [ribose phosphate diphosphokinase complex] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006167 [AMP biosynthetic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0016208 [AMP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0019003 [GDP binding] GO:0019693 [ribose phosphate metabolic process] GO:0030246 [carbohydrate binding] GO:0031100 [organ regeneration] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0043531 [ADP binding] GO:0044249 [cellular biosynthetic process] GO:0070062 [extracellular exosome] Show all	321 aa 35.1 kDa	No	0
PRPS2-005 ENSP00000418911 ENST00000461630	H7C540 [Direct mapping] Ribose-phosphate pyrophosphokinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0044249 [cellular biosynthetic process] Show all	173 aa 18.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.