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PRPS2

GENERAL INFORMATION

Gene name

 PRPS2

Gene description

 Phosphoribosyl pyrophosphate synthetase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in Leydig cells, seminal vesicle and ovarian theca cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB070417
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB070417

GENE INFORMATION

Gene name

 PRPS2

Synonyms

Description

 Phosphoribosyl pyrophosphate synthetase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 12791355 - 12824222

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101911 (version 83.38)

Entrez gene

 5634

UniProt

 P11908 (UniProt - Evidence at protein level)

neXtProt

 NX_P11908

Antibodypedia

 PRPS2 antibodies

PROTEIN BROWSER
PRPS2-001
PRPS2-002
PRPS2-003
PRPS2-004
PRPS2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPS2-001
ENSP00000370043
ENST00000380668
P11908 [Direct mapping]
Ribose-phosphate pyrophosphokinase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004749 [ribose phosphate diphosphokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044249 [cellular biosynthetic process]
GO:0070062 [extracellular exosome]
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 318 aa
34.8 kDa 		No 0
PRPS2-002
ENSP00000419380
ENST00000489404
D3YTJ7 [Direct mapping]
Ribose-phosphate pyrophosphokinase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004749 [ribose phosphate diphosphokinase activity]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0044249 [cellular biosynthetic process]
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 200 aa
22.1 kDa 		No 0
PRPS2-003
ENSP00000370038
ENST00000380663
A6NMS2 [Direct mapping]
Ribose-phosphate pyrophosphokinase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004749 [ribose phosphate diphosphokinase activity]
GO:0009165 [nucleotide biosynthetic process]
Show all
 147 aa
16.1 kDa 		No 0
PRPS2-004
ENSP00000381504
ENST00000398491
P11908 [Direct mapping]
Ribose-phosphate pyrophosphokinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002189 [ribose phosphate diphosphokinase complex]
GO:0004749 [ribose phosphate diphosphokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006015 [5-phosphoribose 1-diphosphate biosynthetic process]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006167 [AMP biosynthetic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0016208 [AMP binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019003 [GDP binding]
GO:0019693 [ribose phosphate metabolic process]
GO:0030246 [carbohydrate binding]
GO:0031100 [organ regeneration]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043531 [ADP binding]
GO:0044249 [cellular biosynthetic process]
GO:0070062 [extracellular exosome]
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 321 aa
35.1 kDa 		No 0
PRPS2-005
ENSP00000418911
ENST00000461630
H7C540 [Direct mapping]
Ribose-phosphate pyrophosphokinase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004749 [ribose phosphate diphosphokinase activity]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0044249 [cellular biosynthetic process]
Show all
 173 aa
18.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.