Expression of PAGE4 in cancer - Summary

GENERAL INFORMATION
Gene name	PAGE4
Gene description	P antigen family, member 4 (prostate associated)
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, prostate cancer)
HPA (cell line):	Group enriched (CACO-2, U-266/70, U-266/84)
HPA (normal tissue):	Group enriched (epididymis, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in placental trophoblasts. Also expressed in seminal vesicle, prostate and in stromal cells in epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA023880
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA023880

GENE INFORMATION
Gene name	PAGE4 (HGNC Symbol)
Synonyms	CT16.7, GAGEC1, PAGE-4
Description	P antigen family, member 4 (prostate associated) (HGNC Symbol)
Entrez gene summary	This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49829260 - 49833973
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101951 (version 83.38)
Entrez gene	9506
UniProt	O60829 (UniProt - Evidence at transcript level)
neXtProt	NX_O60829
Antibodypedia	PAGE4 antibodies

PROTEIN BROWSER

PAGE4-001	PAGE4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAGE4-001 ENSP00000218068 ENST00000218068	O60829 [Direct mapping] P antigen family member 4 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	102 aa 11.2 kDa	No	0
PAGE4-004 ENSP00000365311 ENST00000376141	O60829 [Direct mapping] P antigen family member 4 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	102 aa 11.2 kDa	No	0