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Cytoplasmic expression in placental trophoblasts. Also expressed in seminal vesicle, prostate and in stromal cells in epididymis.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
RNA tissue category: Group enriched (epididymis, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, placenta)
GENE INFORMATION
Gene name
PAGE4 (HGNC Symbol)
Synonyms
CT16.7, GAGEC1, PAGE-4
Description
P antigen family, member 4 (prostate associated) (HGNC Symbol)
Entrez gene summary
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
