Expression of SYP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SYP
Gene description	Synaptophysin
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in islets of Langerhans, neuropil, peripheral nerves and enteroendocrine cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA002858 , CAB000076 , CAB055505
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002858	CAB000076	CAB055505

GENE INFORMATION
Gene name	SYP (HGNC Symbol)
Synonyms	MRX96
Description	Synaptophysin (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49187804 - 49200259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102003 (version 83.38)
Entrez gene	6855
UniProt	P08247 (UniProt - Evidence at protein level)
neXtProt	NX_P08247
Antibodypedia	SYP antibodies

PROTEIN BROWSER

SYP-001	SYP-002	SYP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYP-001 ENSP00000263233 ENST00000263233	P08247 [Direct mapping] Synaptophysin Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0006810 [transport] GO:0006897 [endocytosis] GO:0008021 [synaptic vesicle] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016188 [synaptic vesicle maturation] GO:0030054 [cell junction] GO:0030285 [integral component of synaptic vesicle membrane] GO:0030672 [synaptic vesicle membrane] GO:0042169 [SH2 domain binding] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0043005 [neuron projection] GO:0043195 [terminal bouton] GO:0043621 [protein self-association] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048499 [synaptic vesicle membrane organization] GO:0060076 [excitatory synapse] GO:0071310 [cellular response to organic substance] GO:2000474 [regulation of opioid receptor signaling pathway] Show all	313 aa 33.8 kDa	No	4
SYP-002 ENSP00000418387 ENST00000472598	H7C4W3 [Direct mapping] Synaptophysin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0030285 [integral component of synaptic vesicle membrane] GO:0048168 [regulation of neuronal synaptic plasticity] Show all	203 aa 21.4 kDa	No	2
SYP-004 ENSP00000418169 ENST00000479808	P08247 [Direct mapping] Synaptophysin Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006897 [endocytosis] GO:0008021 [synaptic vesicle] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016188 [synaptic vesicle maturation] GO:0030054 [cell junction] GO:0030285 [integral component of synaptic vesicle membrane] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0043621 [protein self-association] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0048499 [synaptic vesicle membrane organization] GO:2000474 [regulation of opioid receptor signaling pathway] Show all	313 aa 33.8 kDa	No	4