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SYP

GENERAL INFORMATION

Gene name

 SYP

Gene description

 Synaptophysin

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in islets of Langerhans, neuropil, peripheral nerves and enteroendocrine cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA002858 , CAB000076 , CAB055505
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, retina)

GENE INFORMATION

Gene name

 SYP (HGNC Symbol)

Synonyms

 MRX96

Description

 Synaptophysin (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49187804 - 49200259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102003 (version 83.38)

Entrez gene

 6855

UniProt

 P08247 (UniProt - Evidence at protein level)

neXtProt

 NX_P08247

Antibodypedia

 SYP antibodies

PROTEIN BROWSER
SYP-001
SYP-002
SYP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYP-001
ENSP00000263233
ENST00000263233
P08247 [Direct mapping]
Synaptophysin
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0006810 [transport]
GO:0006897 [endocytosis]
GO:0008021 [synaptic vesicle]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0030054 [cell junction]
GO:0030285 [integral component of synaptic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0042169 [SH2 domain binding]
GO:0042734 [presynaptic membrane]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0043621 [protein self-association]
GO:0044306 [neuron projection terminus]
GO:0045202 [synapse]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048172 [regulation of short-term neuronal synaptic plasticity]
GO:0048499 [synaptic vesicle membrane organization]
GO:0060076 [excitatory synapse]
GO:0071310 [cellular response to organic substance]
GO:2000474 [regulation of opioid receptor signaling pathway]
Show all
 313 aa
33.8 kDa 		No 4
SYP-002
ENSP00000418387
ENST00000472598
H7C4W3 [Direct mapping]
Synaptophysin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0030285 [integral component of synaptic vesicle membrane]
GO:0048168 [regulation of neuronal synaptic plasticity]
Show all
 203 aa
21.4 kDa 		No 2
SYP-004
ENSP00000418169
ENST00000479808
P08247 [Direct mapping]
Synaptophysin
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0006897 [endocytosis]
GO:0008021 [synaptic vesicle]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0030054 [cell junction]
GO:0030285 [integral component of synaptic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0043005 [neuron projection]
GO:0043621 [protein self-association]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048172 [regulation of short-term neuronal synaptic plasticity]
GO:0048499 [synaptic vesicle membrane organization]
GO:2000474 [regulation of opioid receptor signaling pathway]
Show all
 313 aa
33.8 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.