Fields »
ABOUT
HELP
BLOG
KPNA3

GENERAL INFORMATION

Gene name

 KPNA3

Gene description

 Karyopherin alpha 3 (importin alpha 4)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046852
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable), cervical cancer (unfavourable) and renal cancer (unfavourable).
Glioma p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046852

GENE INFORMATION

Gene name

 KPNA3 (HGNC Symbol)

Synonyms

 hSRP1, IPOA4, SRP1gamma, SRP4

Description

 Karyopherin alpha 3 (importin alpha 4) (HGNC Symbol)

Entrez gene summary

 The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 49699307 - 49792921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102753 (version 83.38)

Entrez gene

 3839

UniProt

 O00505 (UniProt - Evidence at protein level)

neXtProt

 NX_O00505

Antibodypedia

 KPNA3 antibodies

PROTEIN BROWSER
KPNA3-001
KPNA3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNA3-001
ENSP00000261667
ENST00000261667
O00505 [Direct mapping]
Importin subunit alpha-4
A0A024RDV7 [Target identity:100%; Query identity:100%]
Importin subunit alpha
Show all
Transporters
   Transporter channels and pores
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008022 [protein C-terminus binding]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046718 [viral entry into host cell]
GO:0075732 [viral penetration into host nucleus]
Show all
 521 aa
57.8 kDa 		No 0
KPNA3-002
ENSP00000393869
ENST00000436760
H0Y4S9 [Direct mapping]
Importin subunit alpha-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 91 aa
9.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.