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KPNA3

GENERAL INFORMATION

Gene name

 KPNA3

Gene description

 Karyopherin alpha 3 (importin alpha 4)

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046852
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KPNA3 (HGNC Symbol)

Synonyms

 hSRP1, IPOA4, SRP1gamma, SRP4

Description

 Karyopherin alpha 3 (importin alpha 4) (HGNC Symbol)

Entrez gene summary

 The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 49699307 - 49792921

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102753 (version 83.38)

Entrez gene

 3839

UniProt

 O00505 (UniProt - Evidence at protein level)

neXtProt

 NX_O00505

Antibodypedia

 KPNA3 antibodies

PROTEIN BROWSER
KPNA3-001
KPNA3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNA3-001
ENSP00000261667
ENST00000261667
O00505 [Direct mapping]
Importin subunit alpha-4
A0A024RDV7 [Target identity:100%; Query identity:100%]
Importin subunit alpha
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Transporters
   Transporter channels and pores
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006461 [protein complex assembly]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008022 [protein C-terminus binding]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046718 [viral entry into host cell]
GO:0075732 [viral penetration into host nucleus]
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 521 aa
57.8 kDa 		No 0
KPNA3-002
ENSP00000393869
ENST00000436760
H0Y4S9 [Direct mapping]
Importin subunit alpha-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
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 91 aa
9.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.