Cell atlas - CENPT - The Human Protein Atlas

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CENPT

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CENPT
Gene description	Centromere protein T
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA041220 , HPA058036
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies.

Main location

Nuclear bodies (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041220	HEK 293	Nucleus
	HPA041220	HEK 293	Nuclear bodies
	HPA041220	MCF7	Nucleoplasm
	HPA041220	MCF7	Nuclear bodies
	HPA041220	U-2 OS	Nuclear bodies
	HPA058036	HEK 293	Nuclear bodies
	HPA058036	MCF7	Nuclear bodies
	HPA058036	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	CENPT (HGNC Symbol)
Synonyms	C16orf56, CENP-T, FLJ13111
Description	Centromere protein T (HGNC Symbol)
Entrez gene summary	The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67828157 - 67847811
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102901 (version 83.38)
Entrez gene	80152
UniProt	Q96BT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BT3
Antibodypedia	CENPT antibodies

PROTEIN BROWSER

CENPT-001	CENPT-008	CENPT-010	CENPT-011	CENPT-019	CENPT-027	CENPT-201	CENPT-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CENPT-001 ENSP00000457810 ENST00000562787	Q96BT3 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] GO:0046982 [protein heterodimerization activity] GO:0051276 [chromosome organization] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	561 aa 60.4 kDa	No	0
CENPT-008 ENSP00000457294 ENST00000564817	H3BTR4 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046982 [protein heterodimerization activity] Show all	506 aa 55.1 kDa	No	0
CENPT-010 ENSP00000455638 ENST00000565114	H3BQ71 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.3 kDa	No	0
CENPT-011 ENSP00000454481 ENST00000561593	H3BMP6 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.2 kDa	No	0
CENPT-019 ENSP00000460542 ENST00000567985		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
CENPT-027 ENSP00000457832 ENST00000566758	H3BUW2 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		277 aa 29.6 kDa	No	0
CENPT-201 ENSP00000400140 ENST00000440851	Q96BT3 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0034080 [CENP-A containing nucleosome assembly] GO:0046982 [protein heterodimerization activity] GO:0051276 [chromosome organization] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	561 aa 60.4 kDa	No	0
CENPT-202 ENSP00000487410 ENST00000626059	H3BQS6 [Direct mapping] Centromere protein T Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.