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CENPT

GENERAL INFORMATION

Gene name

 CENPT

Gene description

 Centromere protein T

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in a subset of cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA058036
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA058036

GENE INFORMATION

Gene name

 CENPT (HGNC Symbol)

Synonyms

 C16orf56, CENP-T, FLJ13111

Description

 Centromere protein T (HGNC Symbol)

Entrez gene summary

 The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67828157 - 67847811

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102901 (version 83.38)

Entrez gene

 80152

UniProt

 Q96BT3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96BT3

Antibodypedia

 CENPT antibodies

PROTEIN BROWSER
CENPT-001
CENPT-008
CENPT-010
CENPT-011
CENPT-019
CENPT-027
CENPT-201
CENPT-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPT-001
ENSP00000457810
ENST00000562787
Q96BT3 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
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 561 aa
60.4 kDa 		No 0
CENPT-008
ENSP00000457294
ENST00000564817
H3BTR4 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046982 [protein heterodimerization activity]
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 506 aa
55.1 kDa 		No 0
CENPT-010
ENSP00000455638
ENST00000565114
H3BQ71 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 48 aa
5.3 kDa 		No 0
CENPT-011
ENSP00000454481
ENST00000561593
H3BMP6 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 65 aa
7.2 kDa 		No 0
CENPT-019
ENSP00000460542
ENST00000567985
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 6 aa
0.7 kDa 		No 0
CENPT-027
ENSP00000457832
ENST00000566758
H3BUW2 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 277 aa
29.6 kDa 		No 0
CENPT-201
ENSP00000400140
ENST00000440851
Q96BT3 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0046982 [protein heterodimerization activity]
GO:0051276 [chromosome organization]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
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 561 aa
60.4 kDa 		No 0
CENPT-202
ENSP00000487410
ENST00000626059
H3BQS6 [Direct mapping]
Centromere protein T
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 73 aa
8.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.