Expression of GGA2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GGA2
Gene description	Golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB034422
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), renal cancer (favourable), head and neck cancer (favourable), lung cancer (favourable) and testis cancer (unfavourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Head and neck cancer p<0.001 Lung cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB034422

GENE INFORMATION
Gene name	GGA2 (HGNC Symbol)
Synonyms	KIAA1080, VEAR
Description	Golgi-associated, gamma adaptin ear containing, ARF binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23463542 - 23521995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103365 (version 83.38)
Entrez gene	23062
UniProt	Q9UJY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJY4
Antibodypedia	GGA2 antibodies

PROTEIN BROWSER

GGA2-001	GGA2-002	GGA2-006	GGA2-009	GGA2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGA2-001 ENSP00000311962 ENST00000309859	Q9UJY4 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0006886 [intracellular protein transport] GO:0010008 [endosome membrane] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] GO:0030136 [clathrin-coated vesicle] GO:0030306 [ADP-ribosylation factor binding] GO:0044267 [cellular protein metabolic process] Show all	613 aa 67.1 kDa	Yes	0
GGA2-002 ENSP00000454455 ENST00000567468	H3BMM6 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	223 aa 24.8 kDa	Yes	0
GGA2-006 ENSP00000459560 ENST00000562944	I3L2C4 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	117 aa 12.1 kDa	Yes	0
GGA2-009 ENSP00000459414 ENST00000562117	I3L263 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	129 aa 13.4 kDa	No	0
GGA2-012 ENSP00000455331 ENST00000569300	H3BPI3 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	125 aa 14 kDa	Yes	0