Tissue expression of GGA2 - Summary - The Human Protein Atlas

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GGA2

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GGA2
Gene description	Golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues, including lymphoid tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB034422
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GGA2 (HGNC Symbol)
Synonyms	KIAA1080, VEAR
Description	Golgi-associated, gamma adaptin ear containing, ARF binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23463542 - 23521995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103365 (version 83.38)
Entrez gene	23062
UniProt	Q9UJY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJY4
Antibodypedia	GGA2 antibodies

PROTEIN BROWSER

GGA2-001	GGA2-002	GGA2-006	GGA2-009	GGA2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGA2-001 ENSP00000311962 ENST00000309859	Q9UJY4 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0006886 [intracellular protein transport] GO:0010008 [endosome membrane] GO:0016192 [vesicle-mediated transport] GO:0030131 [clathrin adaptor complex] GO:0030136 [clathrin-coated vesicle] GO:0030306 [ADP-ribosylation factor binding] GO:0044267 [cellular protein metabolic process] Show all	613 aa 67.1 kDa	Yes	0
GGA2-002 ENSP00000454455 ENST00000567468	H3BMM6 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	223 aa 24.8 kDa	Yes	0
GGA2-006 ENSP00000459560 ENST00000562944	I3L2C4 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	117 aa 12.1 kDa	Yes	0
GGA2-009 ENSP00000459414 ENST00000562117	I3L263 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	129 aa 13.4 kDa	No	0
GGA2-012 ENSP00000455331 ENST00000569300	H3BPI3 [Direct mapping] ADP-ribosylation factor-binding protein GGA2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	125 aa 14 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.