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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STX4
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STX4

Gene description

Syntaxin 4

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA001330
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001330

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues generally showed moderate to strong cytoplasmic/membranous staining. Several breast and colon tumors as well as malignant lymphomas showed strong positivity. Skin carcinomas were weakly stained.

GENE INFORMATION

Gene name

STX4 (HGNC Symbol)

Synonyms

p35-2, STX4A

Description

Syntaxin 4 (HGNC Symbol)

Entrez gene summary

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

31032889 - 31042975

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103496 (version 83.38)

Entrez gene

6810

UniProt

Q12846 (UniProt - Evidence at protein level)

neXtProt

NX_Q12846

Antibodypedia

STX4 antibodies

PROTEIN BROWSER

STX4-001
STX4-003
STX4-005
STX4-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STX4-001
ENSP00000317714
ENST00000313843
Q12846 [Direct mapping]
Syntaxin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0000322 [storage vacuole]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007596 [blood coagulation]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016230 [sphingomyelin phosphodiesterase activator activity]
GO:0016323 [basolateral plasma membrane]
GO:0017157 [regulation of exocytosis]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0035493 [SNARE complex assembly]
GO:0035749 [myelin sheath adaxonal region]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0036477 [somatodendritic compartment]
GO:0042581 [specific granule]
GO:0043085 [positive regulation of catalytic activity]
GO:0043197 [dendritic spine]
GO:0043219 [lateral loop]
GO:0043311 [positive regulation of eosinophil degranulation]
GO:0045202 [synapse]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0048284 [organelle fusion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050921 [positive regulation of chemotaxis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
297 aa
34.2 kDa
No 1
STX4-003
ENSP00000378447
ENST00000394998
Q12846 [Direct mapping]
Syntaxin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005773 [vacuole]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007596 [blood coagulation]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016230 [sphingomyelin phosphodiesterase activator activity]
GO:0016323 [basolateral plasma membrane]
GO:0017157 [regulation of exocytosis]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0036477 [somatodendritic compartment]
GO:0042581 [specific granule]
GO:0043085 [positive regulation of catalytic activity]
GO:0043197 [dendritic spine]
GO:0043311 [positive regulation of eosinophil degranulation]
GO:0045202 [synapse]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0048284 [organelle fusion]
GO:0050921 [positive regulation of chemotaxis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
295 aa
33.8 kDa
No 1
STX4-005
ENSP00000390788
ENST00000457779
C9JFM5 [Direct mapping]
Syntaxin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
175 aa
19.8 kDa
No 0
STX4-018
ENSP00000480544
ENST00000613541
A0A087WWW0 [Direct mapping]
Syntaxin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
115 aa
13.1 kDa
No 0

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