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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STX4
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

STX4

Gene description

Syntaxin 4

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA001330
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

STX4 (HGNC Symbol)

Synonyms

p35-2, STX4A

Description

Syntaxin 4 (HGNC Symbol)

Entrez gene summary

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

31032889 - 31042975

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103496 (version 83.38)

Entrez gene

6810

UniProt

Q12846 (UniProt - Evidence at protein level)

neXtProt

NX_Q12846

Antibodypedia

STX4 antibodies

PROTEIN BROWSER

STX4-001
STX4-003
STX4-005
STX4-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STX4-001
ENSP00000317714
ENST00000313843
Q12846 [Direct mapping]
Syntaxin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0000322 [storage vacuole]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007596 [blood coagulation]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016230 [sphingomyelin phosphodiesterase activator activity]
GO:0016323 [basolateral plasma membrane]
GO:0017157 [regulation of exocytosis]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0035493 [SNARE complex assembly]
GO:0035749 [myelin sheath adaxonal region]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0036477 [somatodendritic compartment]
GO:0042581 [specific granule]
GO:0043085 [positive regulation of catalytic activity]
GO:0043197 [dendritic spine]
GO:0043219 [lateral loop]
GO:0043311 [positive regulation of eosinophil degranulation]
GO:0045202 [synapse]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0048284 [organelle fusion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050921 [positive regulation of chemotaxis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
297 aa
34.2 kDa
No 1
STX4-003
ENSP00000378447
ENST00000394998
Q12846 [Direct mapping]
Syntaxin-4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005773 [vacuole]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007596 [blood coagulation]
GO:0008021 [synaptic vesicle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016230 [sphingomyelin phosphodiesterase activator activity]
GO:0016323 [basolateral plasma membrane]
GO:0017157 [regulation of exocytosis]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0033194 [response to hydroperoxide]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0036477 [somatodendritic compartment]
GO:0042581 [specific granule]
GO:0043085 [positive regulation of catalytic activity]
GO:0043197 [dendritic spine]
GO:0043311 [positive regulation of eosinophil degranulation]
GO:0045202 [synapse]
GO:0045785 [positive regulation of cell adhesion]
GO:0048278 [vesicle docking]
GO:0048284 [organelle fusion]
GO:0050921 [positive regulation of chemotaxis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060291 [long-term synaptic potentiation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
295 aa
33.8 kDa
No 1
STX4-005
ENSP00000390788
ENST00000457779
C9JFM5 [Direct mapping]
Syntaxin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
175 aa
19.8 kDa
No 0
STX4-018
ENSP00000480544
ENST00000613541
A0A087WWW0 [Direct mapping]
Syntaxin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
115 aa
13.1 kDa
No 0

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The Human Protein Atlas project is funded
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