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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CTSH

Gene description

Cathepsin H

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, RT4)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA003524 , CAB000458
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003524
CAB000458

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Prostate, endometrial, urothelial, renal, hepatocelluar cancers and malignant lymphomas showed cytoplasmic positivity. Remaining malignancies were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate to strong granular cytoplasmic positivity. Gliomas, melanomas, skin and testis cancers were generally weakly stained or negative.

GENE INFORMATION

Gene name

CTSH (HGNC Symbol)

Synonyms

ACC-4, ACC-5, ACC4, ACC5, CPSB

Description

Cathepsin H (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

78921058 - 78949574

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103811 (version 83.38)

Entrez gene

1512

UniProt

P09668 (UniProt - Evidence at protein level)

neXtProt

NX_P09668

Antibodypedia

CTSH antibodies

PROTEIN BROWSER

CTSH-001
CTSH-007
CTSH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSH-001
ENSP00000220166
ENST00000220166
P09668 [Direct mapping]
Pro-cathepsin H Cathepsin H mini chain Cathepsin H Cathepsin H heavy chain Cathepsin H light chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001913 [T cell mediated cytotoxicity]
GO:0002250 [adaptive immune response]
GO:0002764 [immune response-regulating signaling pathway]
GO:0004175 [endopeptidase activity]
GO:0004177 [aminopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010813 [neuropeptide catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0016505 [peptidase activator activity involved in apoptotic process]
GO:0019882 [antigen processing and presentation]
GO:0030108 [HLA-A specific activating MHC class I receptor activity]
GO:0030335 [positive regulation of cell migration]
GO:0031638 [zymogen activation]
GO:0031648 [protein destabilization]
GO:0032526 [response to retinoic acid]
GO:0033619 [membrane protein proteolysis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043129 [surfactant homeostasis]
GO:0044267 [cellular protein metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060448 [dichotomous subdivision of terminal units involved in lung branching]
GO:0070062 [extracellular exosome]
GO:0070324 [thyroid hormone binding]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:0097208 [alveolar lamellar body]
GO:0097486 [multivesicular body lumen]
GO:2001235 [positive regulation of apoptotic signaling pathway]
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335 aa
37.4 kDa
Yes 0
CTSH-007
ENSP00000435329
ENST00000528741
E9PKT6 [Direct mapping]
Pro-cathepsin H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
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134 aa
14.7 kDa
No 0
CTSH-201
ENSP00000483303
ENST00000615999
A0A087X0D5 [Direct mapping]
Pro-cathepsin H
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
323 aa
36.3 kDa
Yes 0

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