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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CTSH
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CTSH

Gene description

Cathepsin H

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA003524 , CAB000458
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CTSH (HGNC Symbol)

Synonyms

ACC-4, ACC-5, ACC4, ACC5, CPSB

Description

Cathepsin H (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

Chromosome

15

Cytoband

q25.1

Chromosome location (bp)

78921058 - 78949574

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103811 (version 83.38)

Entrez gene

1512

UniProt

P09668 (UniProt - Evidence at protein level)

neXtProt

NX_P09668

Antibodypedia

CTSH antibodies

PROTEIN BROWSER

CTSH-001
CTSH-007
CTSH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSH-001
ENSP00000220166
ENST00000220166
P09668 [Direct mapping]
Pro-cathepsin H Cathepsin H mini chain Cathepsin H Cathepsin H heavy chain Cathepsin H light chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001913 [T cell mediated cytotoxicity]
GO:0002250 [adaptive immune response]
GO:0002764 [immune response-regulating signaling pathway]
GO:0004175 [endopeptidase activity]
GO:0004177 [aminopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010628 [positive regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010813 [neuropeptide catabolic process]
GO:0010815 [bradykinin catabolic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0016505 [peptidase activator activity involved in apoptotic process]
GO:0019882 [antigen processing and presentation]
GO:0030108 [HLA-A specific activating MHC class I receptor activity]
GO:0030335 [positive regulation of cell migration]
GO:0031638 [zymogen activation]
GO:0031648 [protein destabilization]
GO:0032526 [response to retinoic acid]
GO:0033619 [membrane protein proteolysis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043129 [surfactant homeostasis]
GO:0044267 [cellular protein metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060448 [dichotomous subdivision of terminal units involved in lung branching]
GO:0070062 [extracellular exosome]
GO:0070324 [thyroid hormone binding]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:0097208 [alveolar lamellar body]
GO:0097486 [multivesicular body lumen]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
335 aa
37.4 kDa
Yes 0
CTSH-007
ENSP00000435329
ENST00000528741
E9PKT6 [Direct mapping]
Pro-cathepsin H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
134 aa
14.7 kDa
No 0
CTSH-201
ENSP00000483303
ENST00000615999
A0A087X0D5 [Direct mapping]
Pro-cathepsin H
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
323 aa
36.3 kDa
Yes 0

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