Expression of TJP1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TJP1
Gene description	Tight junction protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expressed in cell membranes of most cells, including endothelial cells, most glandular epithelia, Sertoli cells and renal glomeruli.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA001636 , HPA001637 , CAB010822
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001636	HPA001637	CAB010822

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most malignancies showed moderate to strong cytoplasmic positivity. Malignant lymphomas were mainly negative.

GENE INFORMATION
Gene name	TJP1 (HGNC Symbol)
Synonyms	DKFZp686M05161, MGC133289, ZO-1
Description	Tight junction protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	15
Cytoband	q13.1
Chromosome location (bp)	29699367 - 29968865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104067 (version 83.38)
Entrez gene	7082
UniProt	Q07157 (UniProt - Evidence at protein level)
neXtProt	NX_Q07157
Antibodypedia	TJP1 antibodies

PROTEIN BROWSER

TJP1-001	TJP1-002	TJP1-003	TJP1-007	TJP1-008	TJP1-009	TJP1-013	TJP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TJP1-001 ENSP00000281537 ENST00000346128	Q07157 [Direct mapping] Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001825 [blastocyst formation] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0005921 [gap junction] GO:0005923 [bicellular tight junction] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007043 [cell-cell junction assembly] GO:0007605 [sensory perception of sound] GO:0012501 [programmed cell death] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0035329 [hippo signaling] GO:0043296 [apical junction complex] GO:0045177 [apical part of cell] GO:0046581 [intercellular canaliculus] GO:0061024 [membrane organization] GO:0090557 [establishment of endothelial intestinal barrier] GO:1901350 [cell-cell signaling involved in cell-cell junction organization] Show all	1748 aa 195.5 kDa	No	0
TJP1-002 ENSP00000382890 ENST00000400011	G5E9E7 [Direct mapping] Tight junction protein 1 (Zona occludens 1), isoform CRA_e; Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	1692 aa 189.7 kDa	No	0
TJP1-003 ENSP00000452729 ENST00000495972	H0YKB1 [Direct mapping] Tight junction protein 1 (Zona occludens 1), isoform CRA_d; Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0030054 [cell junction] Show all	383 aa 42.5 kDa	No	0
TJP1-007 ENSP00000453334 ENST00000558447	H0YLT6 [Direct mapping] Tight junction protein ZO-1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	231 aa 25.9 kDa	No	0
TJP1-008 ENSP00000441202 ENST00000545208	Q07157 [Direct mapping] Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005923 [bicellular tight junction] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007043 [cell-cell junction assembly] GO:0012501 [programmed cell death] GO:0016323 [basolateral plasma membrane] GO:0030054 [cell junction] GO:0035329 [hippo signaling] GO:0043296 [apical junction complex] GO:0045177 [apical part of cell] GO:0061024 [membrane organization] GO:0090557 [establishment of endothelial intestinal barrier] GO:1901350 [cell-cell signaling involved in cell-cell junction organization] Show all	1668 aa 187 kDa	No	0
TJP1-009 ENSP00000348416 ENST00000356107	G3V1L9 [Direct mapping] Tight junction protein 1 (Zona occludens 1), isoform CRA_a; Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	1768 aa 197.5 kDa	No	0
TJP1-013 ENSP00000382887 ENST00000400007	H0Y3R8 [Direct mapping] Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		227 aa 24.6 kDa	No	0
TJP1-201 ENSP00000483470 ENST00000614355	A0A087X0K9 [Direct mapping] Tight junction protein ZO-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005923 [bicellular tight junction] Show all	1676 aa 187.8 kDa	No	0