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TJP1

GENERAL INFORMATION

Gene name

 TJP1

Gene description

 Tight junction protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Expressed in cell membranes of most cells, including endothelial cells, most glandular epithelia, Sertoli cells and renal glomeruli.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA001636 , HPA001637 , CAB010822
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TJP1 (HGNC Symbol)

Synonyms

 DKFZp686M05161, MGC133289, ZO-1

Description

 Tight junction protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 15

Cytoband

 q13.1

Chromosome location (bp)

 29699367 - 29968865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104067 (version 83.38)

Entrez gene

 7082

UniProt

 Q07157 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07157

Antibodypedia

 TJP1 antibodies

PROTEIN BROWSER
TJP1-001
TJP1-002
TJP1-003
TJP1-007
TJP1-008
TJP1-009
TJP1-013
TJP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TJP1-001
ENSP00000281537
ENST00000346128
Q07157 [Direct mapping]
Tight junction protein ZO-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001825 [blastocyst formation]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005921 [gap junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007043 [cell-cell junction assembly]
GO:0007605 [sensory perception of sound]
GO:0012501 [programmed cell death]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0035329 [hippo signaling]
GO:0043296 [apical junction complex]
GO:0045177 [apical part of cell]
GO:0046581 [intercellular canaliculus]
GO:0061024 [membrane organization]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:1901350 [cell-cell signaling involved in cell-cell junction organization]
Show all
 1748 aa
195.5 kDa 		No 0
TJP1-002
ENSP00000382890
ENST00000400011
G5E9E7 [Direct mapping]
Tight junction protein 1 (Zona occludens 1), isoform CRA_e; Tight junction protein ZO-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0030054 [cell junction]
Show all
 1692 aa
189.7 kDa 		No 0
TJP1-003
ENSP00000452729
ENST00000495972
H0YKB1 [Direct mapping]
Tight junction protein 1 (Zona occludens 1), isoform CRA_d; Tight junction protein ZO-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0030054 [cell junction]
Show all
 383 aa
42.5 kDa 		No 0
TJP1-007
ENSP00000453334
ENST00000558447
H0YLT6 [Direct mapping]
Tight junction protein ZO-1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 231 aa
25.9 kDa 		No 0
TJP1-008
ENSP00000441202
ENST00000545208
Q07157 [Direct mapping]
Tight junction protein ZO-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005921 [gap junction]
GO:0005923 [bicellular tight junction]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007043 [cell-cell junction assembly]
GO:0012501 [programmed cell death]
GO:0016323 [basolateral plasma membrane]
GO:0030054 [cell junction]
GO:0035329 [hippo signaling]
GO:0043296 [apical junction complex]
GO:0045177 [apical part of cell]
GO:0061024 [membrane organization]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:1901350 [cell-cell signaling involved in cell-cell junction organization]
Show all
 1668 aa
187 kDa 		No 0
TJP1-009
ENSP00000348416
ENST00000356107
G3V1L9 [Direct mapping]
Tight junction protein 1 (Zona occludens 1), isoform CRA_a; Tight junction protein ZO-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0030054 [cell junction]
Show all
 1768 aa
197.5 kDa 		No 0
TJP1-013
ENSP00000382887
ENST00000400007
H0Y3R8 [Direct mapping]
Tight junction protein ZO-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 227 aa
24.6 kDa 		No 0
TJP1-201
ENSP00000483470
ENST00000614355
A0A087X0K9 [Direct mapping]
Tight junction protein ZO-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005923 [bicellular tight junction]
Show all
 1676 aa
187.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.